کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5833384 1122621 2013 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Piperine inhibits IL-β induced expression of inflammatory mediators in human osteoarthritis chondrocyte
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Piperine inhibits IL-β induced expression of inflammatory mediators in human osteoarthritis chondrocyte
چکیده انگلیسی
We found that piperine inhibited the production of PGE2 and NO induced by IL-1β. Piperine significantly decreased the IL-1β-stimulated gene expression and production of MMP-3, MMP-13, iNOS and COX-2 in human OA chondrocytes. Piperine inhibited the IL-1β-mediated activation of NF-κB by suppressing the degradation of its inhibitory protein IκBα in the cytoplasm. The present report is first to demonstrate the anti-inflammatory activity of piperine in human OA chondrocytes. Piperine can effectively abrogate the IL-1β-induced over-expression of inflammatory mediators; suggesting that piperine may be a potential agent in the treatment of OA.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Immunopharmacology - Volume 17, Issue 2, October 2013, Pages 293-299
نویسندگان
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