کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5833473 | 1122624 | 2013 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Differential anti-inflammatory and analgesic effects by enantiomers of zaltoprofen in rodents
ترجمه فارسی عنوان
اثرات ضد التهابی و متابولیسم آنتی بیوتیک زلاتوپروفن در جوندگان
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
چکیده انگلیسی
In the present study, we investigated the effect of zaltoprofen enantiomers on inflammation and pain and compared their effect with racemic zaltoprofen. S(+)-zaltoprofen potently inhibited the inflammatory response in carrageenan-induced paw edema model, whereas R(â)-zaltoprofen did not. Moreover, the anti-inflammatory effect of S(+)-zaltoprofen was stronger than that of racemic zaltoprofen, suggesting that S(+)-zaltoprofen is an active component of racemic zaltoprofen in terms of anti-inflammatory activity. In contrast, the results of acetic acid-induced writhing model demonstrated that no significant analgesic effect was observed by racemic zaltoprofen and zaltoprofen enantiomers at doses used in carrageenan-induced paw edema model. However, racemic zaltoprofen and zaltoprofen enantiomers all exerted an analgesic effect at higher doses, which is inconsistent with the result of carrageenan-induced paw edema model. Gastric ulcers induced by racemic zaltoprofen and zaltoprofen enantiomers were minimal. Taken together, these results suggest that S(+)-zaltoprofen is a potent and active anti-inflammatory component of racemic zaltoprofen, but both S(+)-zaltoprofen and R(â)-zaltoprofen might seem to contribute to the analgesic effect of racemic zaltoprofen.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Immunopharmacology - Volume 16, Issue 4, August 2013, Pages 457-460
Journal: International Immunopharmacology - Volume 16, Issue 4, August 2013, Pages 457-460
نویسندگان
Ig Jun Cho, Chang Woo Lee, Myeong Youl Lee, Moo Rim Kang, Jieun Yun, Soo Jin Oh, Sang-Bae Han, Kiho Lee, Song-Kyu Park, Hwan Mook Kim, Sang-Hun Jung, Jong Soon Kang,