The comparison of α-bromo-4-chlorocinnamaldehyde and cinnamaldehyde on coxsackie virus B3-induced myocarditis and their mechanisms

► We compared the therapeutic effects of α-bromo-4-chlorocinnamaldehyde (BCC) with cinnamaldehyde on viral myocarditis (VMC). ► BCC inhibited coxsackie virus B3 replication and cardiac injury in vitro and in vivo. ► The effect of BCC on VMC might be through inhibition of inflammatory signaling. ► These results suggest that BCC had a promising therapeutic effect on VMC.