Nitazoxanide suppresses IL-6 production in LPS-stimulated mouse macrophages and TG-injected mice

► Nitazoxanide suppresses the production of IL-6 from LPS-stimulated macrophages. ► Nitazoxanide inhibits the LPS-induced expression of IL-6 mRNA in RAW 264.7 cells. ► Orally administered nitazoxanide suppresses the increase in IL-6 levels in the blood of thioglycollate-injected mice. ► Nitazoxanide could be a promising lead compound for agents against various diseases associated with overproduction of IL-6.