Anakinra as an interleukin 1 receptor antagonist, complicated genetics and molecular impacts- from the point of view of mouse genomics

► Anakinra is an interleukin-1 (IL-1) receptor antagonist. ► Positive and negative effects of anakinra in treatment of inflammatory disorders. ► The interactions among IL-1rn and its partner are complex. ► Different splicing, background, and environment affect its therapeutic application.