Ac-SDKP ameliorates the progression of lupus nephritis in MRL/lpr mice

► Ac-SDKP treatment reduced renal damage in lupus-prone mice. ► Ac-SDKP suppressed inflammatory infiltration in the kidneys. ► Ac-SDKP inhibited the activation of NF-κB and production of TNF-α. ► Ac-SDKP attenuated renal expression of TGF-β1 and phosphorylation of Smad2/3.