Anti-inflammatory effects of phlorofucofuroeckol B-rich ethyl acetate fraction obtained from Myagropsis myagroides on lipopolysaccharide-stimulated RAW 264.7 cells and mouse edema

► Ethyl acetate fraction of M. myagroides (EFM) inhibited inflammatory response. ► EFM suppressed iNOS and COX-2 expression via inactivation of NF-κB pathway. ► Topical application of EFM reduced mouse ear edema. ► Phlorofucofuroeckol B having anti-inflammatory activity was isolated from EFM. ► EFM could be used as a therapeutic agent for the inflammatory diseases.