Effects of topical pimecrolimus 1% on high-dose ultraviolet B-irradiated epidermal Langerhans cells

► High-dose UVB irradiation induces epidermal LC reduction. ► Topical pimecrolimus 1% can reverse these UVB-induced epidermal LC reduction. ► UVB irradiation plus pimecrolimus treatment does not affect human LC maturation.