کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5833627 1122628 2012 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Cordycepin suppresses TNF-α-induced NF-κB activation by reducing p65 transcriptional activity, inhibiting IκBα phosphorylation, and blocking IKKγ ubiquitination
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Cordycepin suppresses TNF-α-induced NF-κB activation by reducing p65 transcriptional activity, inhibiting IκBα phosphorylation, and blocking IKKγ ubiquitination
چکیده انگلیسی

Cordycepin is reported to participate in multiple pharmacological activities including anti-tumor and anti-inflammation, and is involved in the regulation of NF-κB signaling pathway. However, the detailed molecular mechanism of cordycepin in suppression of NF-κB signaling pathway remains ambiguous. In this study, we first analyzed the effect of cordycepin on NF-κB activity in HEK-293T cells, and found that cordycepin resulted in a dose-dependent reduction in TNF-α-induced NF-κB activation. Although cordycepin did not block TNF-α-induced nuclear translocation of p65, high concentration of cordycepin reduced the DNA-binding and transcriptional activities of NF-κB. Moreover, cordycepin also inhibited IκBα phosphorylation so as to suppress the degradation of IκBα. Further investigation revealed that cordycepin suppressed IKKs-mediated NF-κB activation and inhibited the ubiquitination of IKKγ. In conclusion, cordycepin effectively inhibits NF-κB signaling through suppressing the activities of NF-κB, IκB and IKK. Thus, cordycepin may provide some potential therapeutic application in inflammation-associated disorders and cancer.

► Cordycepin resulted in a dose-dependent reduction in TNF-α-induced NF-κB activation. ► Cordycepin reduced p65 transcriptional activity at high concentration. ► Cordycepin inhibited IκBα phosphorylation. ► Cordycepin inhibited IKKs-mediated NF-κB activation. ► Cordycepin suppressed IKKγ ubiquitination in a dose-dependent manner.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Immunopharmacology - Volume 14, Issue 4, December 2012, Pages 698-703
نویسندگان
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