Antitumor and immunomodulatory properties of artemether and its ability to reduce CD4+ CD25+ FoxP3+ T reg cells in vivo

► Artemether suppresses the progression of tumor tissues in tumor-bearing mice. ► Artemether depletes splenic CD4+CD25+Foxp3+ Treg cells in tumor-bearing mice. ► ART significantly increases the production of IL-4 from splenic cells in tumor-bearing mice.