کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5833792 1122633 2011 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
ReviewResolving the identity myth: Key markers of functional CD4+FoxP3+ regulatory T cells
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
ReviewResolving the identity myth: Key markers of functional CD4+FoxP3+ regulatory T cells
چکیده انگلیسی

Authenticating markers for the functional suppressive CD4+FoxP3+ regulatory T cells (Tregs) are important for the quantitative identification and enrichment of viable Tregs for possible therapeutic use. CD25 as a surrogate marker of Tregs has some limitations, which prompted investigators to identify more specific marker(s) of Tregs. The search for a firm molecular definition of Tregs resulted in the identification of FoxP3 as a better marker of this subset of CD4 cells. Nevertheless, FoxP3+ Tregs are phenotypically and functionally heterogeneous. Even in normal mice, only a minority of FoxP3+ T cells are potent suppressor cells. Therefore, additional marker(s) are required for delineation of truly functional Tregs. In this review, the studies identifying markers of functional Tregs, both in mouse and in human, and their functional implications are discussed. Our finding that TNFR2, which mediates the effect of TNF on the activation of Tregs, is a superb marker of the most suppressive subset of mouse Tregs and its application in the identification of functional human Tregs will also be reviewed.

► FoxP3+ Tregs are phenotypically and functionally heterogeneous. ► Additional markers are needed to identify highly potent functional Tregs. ► A number of molecules or their combinations have provided useful tools in the delineation of functional Tregs. ► Identification of these molecules also has advanced our understanding of biological processes of Tregs. ► Identification of a more specific Treg cell marker(s), especially if expressed on the surface of functional Tregs, is still needed.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Immunopharmacology - Volume 11, Issue 10, October 2011, Pages 1489-1496
نویسندگان
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