A phytoceramide analog stimulates the production of chemokines through CREB activation in human endothelial cells

► C24(2′OH)Phy was isolated as immunomodulator using a Drosophila ex vivo culture system. ► C24(2′OH)Phy selectively activates the transcription of inflammatory response genes, including chemokines in human cells. ► C24(2′OH)Phy stimulates chemokine production through cAMP response element-binding protein activation in human cells.