Honokiol isolated from Magnolia officinalis stimulates osteoblast function and inhibits the release of bone-resorbing mediators

► Honokiol caused an elevation of osteoblast growth and differentiation. ► Honokiol increased glutathione content and osteoprotegerin release in MC3T3-E1 cells. ► Honokiol decreased the production of osteoclast differentiation inducing factors.