کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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5833825 | 1122633 | 2011 | 7 صفحه PDF | دانلود رایگان |

As an important immune mediator, PGE2 plays an important role in the immune tolerance, autoimmune diseases, immune regulation and tumor immunotolerance. PGE2 is considered to be a promising candidate for the control of the immune diseases. To further understand the immuno-modulating effects of PGE2 on CD4+ T cells, in vitro investigation was conducted in the present study. The results showed that PGE2 inhibited the proliferation of T cells in vitro in a dose-dependent manner. Gene expression profiling showed that 1716 genes were down regulated and 73 genes were up regulated with a change of 1.5 fold. Several signal transduction pathways were involved, such as TNF-α and NF-kB signaling pathway, T cell receptor signaling pathway, IL-2 signaling pathway, and MAPK pathway. The results showed that PGE2 inhibited IFN-γ, TNF-α and IL-4 production by CD4+ T cells 24 h after cell culture. A comparison between IFN-γ and IL-4 production showed that PGE2 enhanced the relative ratio of IL-4 to IFN-γ in CD4+ T cells culture, and regulated CD4+ T cells toward Th2 cell development. The results of the present study indicated that PGE2 has the potential to treat Th1-mediated inflammatory diseases by regulating CD4+ T cells toward Th2 cell immune response.
⺠In this study we address the role of PGE2 as a modulator of the immune response in vitro. ⺠PGE2 inhibits the proliferation of CD4+ T cells in a dose-dependent manner. ⺠PGE2 down-regulates the expression of immune regulation genes in CD4+ T cells. ⺠PGE2 inhibited IFN-γ and TNF-α production by CD4+ T cells 24 h and 48 h after cell culture respectively. ⺠PGE2 enhanced the IL-4/IFN-γ ratio in CD4+ T cells culture, and regulated CD4+ T cells toward Th2 polarization.
Journal: International Immunopharmacology - Volume 11, Issue 10, October 2011, Pages 1599-1605