Pharmacokinetic/pharmacodynamic analyses of chymase inhibitor SUN13834 in NC/Nga mice and prediction of effective dosage for atopic dermatitis patients

► Pharmacokinetic/pharmacodynamic analyses of chymase inhibitor SUN13834 were examined. ► Minimum effective concentration (MEC) was 0.13-0.2 ng/mL in acute dermatitis model. ► Maintenance of the MEC for at least 10-12 h was necessary for NC/Nga mice. ► The dose regimen for human atopic dermatitis treatment was determined by this study. ► Providing the information for determining dose regimen without appropriate biomarker.