Innate defense regulator peptide synergizes with CpG ODN for enhanced innate intestinal immune responses in neonate piglets

► Using neonatal piglets model, we investigated the innate intestinal immune responses to CpG ODN-HH2. ► We detected an increase in Th1 responses in mucosal immune system. ► Th1 responses were correlated with an obvious cellular infiltration in mucosal immune system.