Arctigenin promotes degradation of inducible nitric oxide synthase through CHIP-associated proteasome pathway and suppresses its enzyme activity

► Arctigenin promotes degradation of iNOS through CHIP-associated proteasome pathway. ► Arctigenin decreases iNOS phosphorylation through inhibiting ERK and Src. ► Arctigenin suppresses iNOS enzyme activity. ► Arctigenin could regulate iNOS at multiple levels.