IL-17A-producing NK cells were implicated in liver injury induced by ischemia and reperfusion

► NK cells increased IL-17A production after liver IRI. ► Multiple cytokines regulate IL-17A production produced by NK cells in liver IRI. ► Depletion of NK cells attenuates liver IRI. ► Neutralization of IL-17A attenuated liver IRI in Rag1 −/− mice.