Hepatocyte growth factor-induced BMP-2 expression is mediated by c-Met receptor, FAK, JNK, Runx2, and p300 pathways in human osteoblasts

► HGF induces BMP-2 expression in osteoblasts. ► c-Met receptor is mediated HGF effects. ► HGF induces BMP-2 through c-Met receptor/FAK/JNK/Runx2 and p300.