Inhibitory effect of the antidepressant imipramine on NF-κB-dependent CXCL1 expression in TNFα-exposed astrocytes

► Imipramine is a tricyclic antidepressant. ► Imipramine inhibits NF-κB-mediated CXCL1 expression in astrocytes. ► Astrocyte-derived CXCL1 facilitates microglial cell migration. ► Imipramine inhibits microglial cell migration. ► Imipramine exerts suppressive effects on neuroinflammation.