Effect of erythromycin on cigarette-induced histone deacetylase protein expression and nuclear factor-κB activity in human macrophages in vitro

► EM increases cigarette-induced declines in HDAC1, 2, 3 protein expression. ► EM inhibits cigarette-increased NF-κB activity and protein expression. ► EM suppresses cigarette-mediated IL-8 and TNF-a protein release. ► EM increases HDAC expression which may be associated with inhibition of NF-κB and cytokine.