Increased production of nitric oxide by neutrophils from patients with chronic granulomatous disease on interferon-gamma treatment

► We measured nitric oxide (NO) levels of sera and neutrophils in 19 patients with CGD. ► Patients who received IFN-γ showed higher NO in their serum. ► NO levels from their neutrophils increased significantly after adding IFN-γ in vitro. ► Increased NO production by IFN-γ could be a mechanism for its therapeutic effect in CGD patients.