3′-Chloro-5,7-dimethoxyisoflavone inhibits TNFα-induced CXCL10 gene transcription by suppressing the NF-κB pathway in HCT116 human colon cancer cells

► 3′-Chloro-5,7-dimethoxyisoflavone (CDMF) is a synthetic isoflavone derivative. ► CDMF inhibits TNFα-induced transcriptional activation of the CXCL10 gene promoter. ► CDMF inhibited TNFα-induced IκB phosphorylation. ► CDMF suppresses TNFα-induced CXCL10 production through inhibition of NF-κB in HCT116 cells.