کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5834558 | 1560373 | 2016 | 20 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Traditional Chinese medicine formulas for the treatment of osteoporosis: Implication for antiosteoporotic drug discovery
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کلمات کلیدی
Kaempferol (PubChem CID: 5280863)Catalpol (PubChem CID: 91520)Emodin (PubChem CID: 3220)Cinnamaldehyde (PubChem CID: 637511)Formononetin (PubChem CID: 5280378)Clinical use - استفاده بالینیFerulic acid (PubChem CID: 445858) - اسید فرولیک (PubChem CID: 445858)Active ingredients - عناصر فعالAction mechanism - مکانیسم عملOsteoporosis - پوکی استخوان
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
داروشناسی
پیش نمایش صفحه اول مقاله
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چکیده انگلیسی
Clinical practice and animal experiments indicate that TCM formulas provide a definite therapeutic effect on osteoporosis. The active constituents in TCM formulas are diverse in chemical structure, and include flavonoids, lignans, saponins and iridoid glycosides. Antiosteoporotic mechanism of TCM formulas and herbs involves multi regulatory pathways, such as Wnt/β-catenin, BMP/Smad, MAPK pathway and RANKL/OPG system. Phytochemicals from TCM formulas and their compositional herb medicines offer great potential for the development of novel antiosteoporotic drugs. The active ingredients in TCM formulas can be developed in combination as potent drugs, which may exhibit better antiosteoporotic effects compared to the individual compound.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Ethnopharmacology - Volume 189, 2 August 2016, Pages 61-80
Journal: Journal of Ethnopharmacology - Volume 189, 2 August 2016, Pages 61-80
نویسندگان
Nai-Dan Zhang, Ting Han, Bao-Kang Huang, Khalid Rahman, Yi-Ping Jiang, Hong-Tao Xu, Lu-Ping Qin, Hai-Liang Xin, Qiao-Yan Zhang, Yi-min Li,