Reproductive toxicology and clastogenic evaluation in mice of a phytotherapeutic formulation obtained from Cinchona calisaya Weddel (Rubiaceae) used in Brazilian folk medicine as female fertility stimulant

Aim of the study: To investigate possible toxic reproductive effects caused by exposition to the “água inglesa®” in period early (before of mating), pre and post-embryo implantation in mice, in order for corroborate, or not, the validity of this product as female fertility stimulant, as well as, to colaborate with your secure use. Besides, clastogenic potential was evaluated using micronucleus assay.111