The neuroprotective effect of modified “Shengyu” decoction is mediated through an anti-inflammatory mechanism in the rat after traumatic brain injury

In conclusion, the present study suggests that MSD may be a potential therapeutic for the treatment of TBI because MSD alleviated secondary brain injury induced by TBI. In addition, MSD inhibited the inflammatory response through reducing the expression of inflammatory cytokines and the activation of microglial cells and astrocytes in the brain tissue of rat after TBI. Therefore, a potential anti-inflammatory mechanism of the “Shengyu” decoction was confirmed, which may be one of the main reasons of “Shengyu” decoction used to treat diseases with obvious inflammatory responses, such as long sores with heavy pus.92