An LC/MS/MS method for simultaneous quantitation of two homoisoflavones: Protosappanin B and brazilin with hypoglycemic activity in rat plasma and its application to a comparative pharmacokinetic study in normal and streptozotocin-treated rats

Mean plasma concentration-time curves of protosappanin B (a) and brazilin (b) after oral administration of Sappan Lignum extract at 2.83 g/kg in normal and streptozotocin-treated groups (n=6). 46