کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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5838080 | 1123976 | 2013 | 9 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: A 26-week repeated dose toxicity study of Xian-ling-gu-bao in Sprague-Dawley rats A 26-week repeated dose toxicity study of Xian-ling-gu-bao in Sprague-Dawley rats](/preview/png/5838080.png)
Ethnopharmacological relevanceXian-ling-gu-bao (XLGB) is a traditional Chinese prescription commonly used to treat osteoporosis, osteoarthritis, aseptic bone necrosis, climacteric syndrome, and bone fracture. However, there is limited toxicological information available on XLGB in preclinical animal model studies. It has also been recently reported that XLGB may be related to liver injury in humans.Aim of studyThis study was designed to determine the potential toxic effects of XLGB, particularly hepatotoxicity, in Sprague-Dawley rats following oral administration for up to 26 weeks.Materials and methodsMale and female rats were administered XLGB by oral gavage at doses of 0, 100, 300, and 1000Â mg/kg for 26 weeks followed by a recovery period of 4 weeks. Clinical signs, body weight, food consumption, ophthalmology, hematology, coagulation, serum chemistry, urinalysis, bone mineral density, hormone concentration, organ weights and histopathology were examined at the end of 13- and 26-week dosing period as well as after the recovery period.ResultsNeither hepatotoxicity nor any other toxic effects were observed in the XLGB treated rats at doses up to 1000Â mg/kg for 26 weeks except for a slight increase in the organ weight of the uterus in female rats at doses higher than 300Â mg/kg on week 26.ConclusionsIn this study, we found the no-observed-adverse-effect level (NOAEL) for XLGB in Sprague-Dawley rats was 1000Â mg/kg, a dose that was equivalent to 3.3 times human dose based on body surface area.
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Journal: Journal of Ethnopharmacology - Volume 145, Issue 1, 9 January 2013, Pages 85-93