The effect of Compound Danshen Dripping Pills, a Chinese herb medicine, on the pharmacokinetics and pharmacodynamics of warfarin in rats

The plasma concentration versus time profile of warfarin (A) and the prothrombin time versus time profile of warfarin (B) determined after application of a single oral dose (1 mg/kg) of warfarin to control rats and to those that had received daily treatment with CDDP (n = 6).