Anti-inflammatory and antinociceptive properties of the leaves of Eriobotrya japonica

The butanolic extract of Eriobotrya japonica leaves (LEJ) showed potent inhibitory effects on the inflammatory mediators including nitric oxide, iNOS, COX-2, TNF-α and IL-6 via the attenuation of NF-κB translocation to the nucleus. LEJ also exhibited excellent antinociceptive activity in both central and peripheral mechanism as a weak opioid agonist.