Induction of insulin secretion by an aqueous extract of Tabernanhte iboga Baill. (Apocynaceae) in rat pancreatic islets of Langerhans

The aqueous extract of Tabernanthe iboga (TBEt) stimulated insulin secretion in dose- and glucose (G)-dependent manners by inducing the closure of K+-ATP channels and the intensification of Ca2+ influx through voltage-dependent calcium channels.