Vasorelaxation by extracts of Casimiroa spp. in rat resistance vessels and pharmacological study of cellular mechanisms

Seed and leaf extracts of Casimiroa spp. induce vasorelaxation in rat caudal and aortic tissues; the effects are dependent from M3 receptor and cGMP-dependent NO pathway. The results support the traditional use of Casimiroa decoctions as antihypertensive in the Mexican ethnomedicine.