Atrazine acts as an endocrine disrupter by inhibiting cAMP-specific phosphodiesterase-4

► Atrazine stimulates cAMP accumulation in pituitary and Leydig cells. ► Atrazine also stimulates PRL and androgens secretion. ► Stimulatory effects of atrazine were abolished in cells with IBMX-inhibited PDEs. ► Atrazine specificity toward cAMP-specific PDEs was indicated by no changes in cGMP. ► Rolipram, a specific PDE4 inhibitor, also prevents stimulatory effects of atrazine. ► Atrazine acts as an endocrine disrupter by inhibiting cAMP-specific PDE4.