Genome-wide gene expression effects in B6C3F1 mouse intestinal epithelia following 7 and 90Â days of exposure to hexavalent chromium in drinking water

► Mouse small intestine gene expression is highly responsive to hexavalent chromium [Cr(VI)]. ► Cr(VI) elicits more differential gene expression after 7 days of exposure than 90 days of exposure. ► Oral exposure to Cr(VI) leads to oxidative stress, cell cycle, lipid and immune dysregulation. ► Cr(VI) elicits dose-dependent changes in gene expression with an overall median EC50 of 47 mg/L SDD.