Kaempferol regulates OPN-CD44 pathway to inhibit the atherogenesis of apolipoprotein E deficient mice

► OPN-CD44 pathway plays a critical role in the development of atherosclerosis. ► We examine lesion area, OPN and CD44 changes after kaempferol treatment. ► Kaempferol treatment decreased atherosclerotic lesion area in ApoE−/− mice. ► Kaempferol treatment decreased aortic OPN and CD44 expressions in ApoE−/− mice. ► Kaempferol regulates OPN-CD44 pathway to inhibit the atherogenesis.