The effect of methylsulfonylmethane on the experimental colitis in the rat

► Methylsulfonylmethane occurs naturally in some green plants, fruits and vegetables. ► Methylsulfonylmethane (MSM) has anti-inflammatory and antioxidant effects. ► We evaluated the effects of MSM in a rat model of experimental ulcerative colitis. ► MSM has protective effect against acetic acid-induced colitis in rat.