کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5847065 | 1129350 | 2013 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Mechanisms of dopamine transporter regulation in normal and disease states
ترجمه فارسی عنوان
مکانیسم تنظیم مقررات انتقال دهنده دوپامین در حالت های طبیعی و بیماری
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کلمات کلیدی
کوکائین، آمفتامین، اعتیاد به مواد مخدر، اختلال بیش فعالی کمبود توجه، اختلال دو قطبی، بیماری پارکینسون،
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب سلولی و مولکولی
چکیده انگلیسی
The dopamine (DA) transporter (DAT) controls the spatial and temporal dynamics of DA neurotransmission by driving reuptake of extracellular transmitter into presynaptic neurons. Many diseases such as depression, bipolar disorder, Parkinson's disease (PD), and attention deficit hyperactivity disorder (ADHD) are associated with abnormal DA levels, implicating DAT as a factor in their etiology. Medications used to treat these disorders and many addictive drugs target DAT and enhance dopaminergic signaling by suppressing transmitter reuptake. We now understand that the transport and binding properties of DAT are regulated by complex and overlapping mechanisms that provide neurons with the ability to modulate DA clearance in response to physiological demands. These processes are controlled by endogenous signaling pathways and affected by exogenous transporter ligands, demonstrating their importance for normal neurotransmission, drug abuse, and disease treatments. Increasing evidence supports the disruption of these mechanisms in DA disorders, implicating dysregulation of transport in disease etiologies and suggesting these processes as potential points for therapeutic manipulation of DA availability.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Trends in Pharmacological Sciences - Volume 34, Issue 9, September 2013, Pages 489-496
Journal: Trends in Pharmacological Sciences - Volume 34, Issue 9, September 2013, Pages 489-496
نویسندگان
Roxanne A. Vaughan, James D. Foster,