کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5848633 | 1561699 | 2016 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Nanotoxicological study of polyol-made cobalt-zinc ferrite nanoparticles in rabbit
ترجمه فارسی عنوان
بررسی نانوکسیکولوژی نانوذرات فریت کبالت-روی روی پلی اتیلن در خرگوش
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کلمات کلیدی
نانوذرات فریت کبالت-روی، فرایند پلیول سلول اندوتلیال، سمیت مسمومیت، خرگوش نیوزیلند،
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
چکیده انگلیسی
The increasing use of engineered nanomaterials in commercial manufacturing and consumer products presents an important toxicological concern. Superparamagnetic zinc-cobalt ferrite nanoparticles (SFN) emerge as a promising tool for early cancer diagnostics and targeted therapy. However, toxicity and biological activities of SFN should be evaluated in vitro and in vivo in animal before any clinical application. In this study we aim to synthesize and characterize such objects using polyol process in order to assess its nanotoxicological profile in vitro as well as in vivo. The produced particles consist of a cobalt-zinc ferrite phase corresponding to the Zn0.8Co0.2Fe2O4 composition. They are isotropic in shape single crystals of 8 nm in size. The thermal variation of their dc-magnetization confirms their superparamagnetic behavior. In vitro, acute exposure (4 h) to them (100 μg mLâ1) induced an important decrease of healthy Human Umbilical Vein Endothelial Cells (HUVECs) viability. In vivo investigation in New-Zealand rabbits revealed that they lead to tissue toxicities; in lungs, liver and kidneys. Our investigations report, for the first time as far as we know, that SFN exhibit harmful properties in human cells and mammals.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Environmental Toxicology and Pharmacology - Volume 45, July 2016, Pages 321-327
Journal: Environmental Toxicology and Pharmacology - Volume 45, July 2016, Pages 321-327
نویسندگان
Amel Hanini, Mohamed El Massoudi, Julie Gavard, Kamel Kacem, Souad Ammar, Ouajdi Souilem,