کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5848818 | 1130674 | 2015 | 26 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Effect of low carbohydrate high protein (LCHP) diet on lipid metabolism, liver and kidney function in rats
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کلمات کلیدی
SCD-1VLDLCardio-vascular diseasesTCHHDLstearoyl-CoA desaturaseALTqRT-PCRFASReal-time PCR - PCR به موقعAST - آسپارتات ترانس آمینازalanine transaminase - آلانین ترانس آمینازfatty acid synthase - اسید چرب سنتازaspartate transaminase - ترانس آمیناز آسپارتاتTriacylglycerols - ترشیال گلیسیرینTAG یا triacylglycerols - تری گلیسرید یا تری آسیل گلیسرولWestern diet - رژیم غربیKidney function - عملکرد کلیهhigh density lipoprotein - لیپوپروتئین با چگالی بالاvery-low-density lipoprotein - لیپوپروتئین با چگالی کمlow density lipoprotein - لیپوپروتئین چگالی کمLDL - لیپوپروتئین کم چگالی(کلسترول بد)Lipid metabolism - متابولیسم لیپیدWistar rats - موش های صحرایی Wistarbody weight - وزن بدنtotal cholesterol - کلسترول تام
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The objective of this study was to compare effects of Western diet (WD) with low carbohydrate high protein (LCHP) diet on lipid metabolism, liver and kidney function in rats. Eighteen rats were randomly assigned to three experimental groups and fed for the next 2 months. The experimental diets were: Control (7% of soybean oil, 20% protein), WD (21% of butter, 20% protein), and LCHP (21% of butter and 52.4% protein) diet. The LCHP diet significantly decreased the body weight of the rats. Diet consumption was differentiated among groups, however significant changes were observed since third week of the experiment duration. Rats fed LCHP diet ate significantly less (25.2Â g/animal/day) than those from Control (30.2Â g/animal/day) and WD (27.8Â g/animal/day) groups. Additionally, food efficiency ratio (FER) tended to decrease in LCHP fed rats. Serum homocysteine concentration significantly decreased in rats fed WD and LCHP diets. Liver weights were significantly higher in rats fed WD and LCHP diets. At the end of the experiment (2 months) the triacylglycerol (TAG) was significantly decreased in animals fed LCHP compared to WD. qRT-PCR showed that SCD-1 and FAS were decreased in LCHP fed rats, but WD diet increased expression of lipid metabolism genes. Rats receiving LCHP diet had two fold higher kidney weight and 54.5% higher creatinin level compared to Control and WD diets. In conclusion, LCHP diet decreased animal's body weight and decreased TAG in rat's serum. However, kidney damage in LCHP rats was observed.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Environmental Toxicology and Pharmacology - Volume 39, Issue 2, March 2015, Pages 713-719
Journal: Environmental Toxicology and Pharmacology - Volume 39, Issue 2, March 2015, Pages 713-719
نویسندگان
Renata B. Kostogrys, Magdalena Franczyk-Å»arów, Edyta MaÅlak, Kinga Topolska,