Keywords: ACC; acetyl-CoA carboxylase; ASTX; astaxanthin; BAMBI; BMP and activin membrane-bound inhibitor homolog; BDL; bile duct ligation; CCL4; chemokine (C-C motif) ligand 4; CCR; chemokine receptor C-C motif; ChREBP; carbohydrate response element binding protei
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Keywords: ALT; alanine aminotransferase; ChREBP; carbohydrate response element binding protein; CXCL10; CXC motif chemokine ligand 10; DGAT2; diglyceride acyltransferase 2; DNL; de novo lipogenesis; FAME; fatty acid methyl ester; FAS; fatty acid synthase; GAPDH; gl
Keywords: Progesterone; Testosterone; Metabolites; Streptozotocin; Peripheral nerve; 3α-diol; 5α-androstane-3α,17β-diol; ACC; acetyl-CoA carboxylase α; AR; androgen receptor; DPN; diabetic peripheral neuropathy; DHP; dihydroprogesterone; ESI; electrospray ioni
Keywords: ACOX-1; acyl-CoA oxidase 1; AdipoQ; adiponectin; BCE; black currant extract; CD68; cluster of differentiation 68; CLS; crown-like structures; CTP-1; carnitine palmotyoltransferase 1; CVD; cardiovascular disease; DIO; diet-induced obesity; FAS; fatty acid
Cissus quadrangularis extract (CQR-300) inhibits lipid accumulation by downregulating adipogenesis and lipogenesis in 3T3-L1 cells
Keywords: ACC; acetyl-CoA carboxylase; AMPK; AMP-activated protein kinase; aP2; fatty acid binding protein (aP2); BCS; bovine calf serum; C/EBPα; CCAAT/enhancer-binding protein α; CQR-300; Cissus quadrangularis extract; DMEM; Dulbecco's modified Eagle's mediu
Pedunculoside, a novel triterpene saponin extracted from Ilex rotunda, ameliorates high-fat diet induced hyperlipidemia in rats
Keywords: Triterpene saponin; Hyperlipidemia; PPAR-α; SREBP-1c; FAS; SCD-1;
PMFs-rich Citrus extract prevents the development of non-alcoholic fatty liver disease in C57BL/6J mice induced by a high-fat diet
Keywords: NAFLD; non-alcoholic fatty liver disease; NASH; non-alcoholic steatohepatitis; Nrf2; nuclear factor erythroid-2 related factor 2; DIO; diet -induced obese; TGs; triglycerides; ROS; reactive oxygen species; Keap1; Kelch-like ECH-associated protein 1; NQO1;
Polydatin prevents fructose-induced liver inflammation and lipid deposition through increasing miR-200a to regulate Keap1/Nrf2 pathway
Keywords: ASC; apoptosis-associated speck-like protein; CPT-1; carnitine palmitoyl transferase-1; GST; glutathione S-transferase; HO-1; hemeoxygenase-1; H2O2; hydrogen peroxide; IL; interleukin; Keap1; Kelch-like ECH-associated protein 1; MDA; malondialdehyde; miR-
Bioactive Lipid Species and Metabolic Pathways in Progression and Resolution of Nonalcoholic Steatohepatitis
Keywords: Nonalcoholic Fatty Liver Disease; Triglycerides; Fatty Acids; Therapy; AA; arachidonic acid; ACC; acetyl-coenzyme A carboxylase; ASMase; acid sphingomyelinase; CeS; ceramide synthase; CoA; coenzyme A; COX; cyclo-oxygenase; DES; dihydro-ceramide desatura
Lipid droplets induced by secreted phospholipase A2 and unsaturated fatty acids protect breast cancer cells from nutrient and lipotoxic stress
Keywords: AA; arachidonic acid; AMPK; AMP-dependent protein kinase; ATGL; adipose triglyceride lipase; cPLA2α; cytosolic group IVA PLA2; CPT1; carnitine O-palmitoyltransferase 1; CPT1A; the liver isoform of CPT1; DGAT1; diacylglycerol acyltransferase 1; DHA; docos
Natural products as modulators of the nuclear receptors and metabolic sensors LXR, FXR and RXR
Keywords: Natural products; Nuclear receptors; Liver X receptor; Farnesoid X receptor; Retinoid X receptor; Metabolic syndrome; Precision medicine; 6-ECDCA; 6α-ethyl-chenodeoxycholic acid (obeticholic acid); AA; arachidonic acid; ABC; ATP-binding cassette transpor
Increased FNDC5/Irisin expression in human hepatocellular carcinoma
Keywords: FNDC5; fibronectin type III domain containing 5; DNL; de novo lipogenesis; HCC; human hepatocellular carcinoma; SCD-1; stearoyl-CoA desaturase; NOTCH-1; Neurogenic locus notch homolog protein 1; SREBF-1; sterol regulatory element-binding factor 1; SFA;
Red paprika (Capsicum annuum L.) and its main carotenoid capsanthin ameliorate impaired lipid metabolism in the liver and adipose tissue of high-fat diet-induced obese mice
Keywords: NAFLD; non-alcoholic fatty liver disease; WAT; white adipose tissue; ND; normal diet; HD; high-fat diet; RP; red paprika-supplemented diet; CS; capsanthin-supplemented diet; TG; triacylglycerol; TC; total cholesterol; HDL; high-density lipoprotein; NEFA;
Leptin concentrations and SCD-1 indices in classical homocystinuria: Evidence for the role of sulfur amino acids in the regulation of lipid metabolism
Keywords: AdoHcy; S-adenosylhomocysteine; AdoMet; S-adenosylmethionine; BIA; bioelectrical impedance analysis; BMD; bone mineral density; CβS; cystathionine β-synthase; DXA; dual X-ray absorptiometry; FAMEs; fatty acid methyl esters; GSH; glutathione; HCU; classi
Astaxanthin inhibits inflammation and fibrosis in the liver and adipose tissue of mouse models of diet-induced obesity and nonalcoholic steatohepatitis
Keywords: ACOX-1; acyl-coenzyme A oxidase 1; ALT; alanine aminotransferase; apoE; apolipoprotein E; Arg-1; arginase-1; ASTX; astaxanthin; Casp; caspase; CVD; cardiovascular disease; CPT-1α; carnitine palmitoyltransferase 1α; CD68; cluster of differentiation 68; C
Ageing sensitized by iPLA2β deficiency induces liver fibrosis and intestinal atrophy involving suppression of homeostatic genes and alteration of intestinal lipids and bile acids
Keywords: ACC; acetyl-CoA carboxylase; ATF6; activating transcription factor6; AB-PAS; alcian blue-periodic acidschiff; ACC; acetyl-CoA carboxylase; ACSL; long-chain acyl-CoA synthetase; Bad; Bcl-2-associated death promoter; Bax; Bcl-2-like protein 4; Bcl-2; B-cell
1-Deoxynojirimycin isolated from Bacillus subtilis improves hepatic lipid metabolism and mitochondrial function in high-fat-fed mice
Keywords: DNJ; 1-deoxynojirimycin; IR; insulin resistance; T2DM; type 2 diabetes; WAT; white adipose tissue; C/EBPα; ccaat-enhancer-binding protein α; ACC; acetyl-CoA carboxylase; FAS; fatty acid synthase; SCD-1; stearoyl CoA desaturase 1; CD36; cluster of differ
Fenofibrate insulates diacylglycerol in lipid droplet/ER and preserves insulin signaling transduction in the liver of high fat fed mice
Keywords: DNL; de novo lipogenesis; IRS1; insulin-receptor-substrate 1; FB; fenofibrate; GTT; glucose tolerance test; β-HAD; β3-hydroxyacyl-CoA dehydrogenase; LCACoA; long chain acyl-CoA; DAG; diacylglycerol; GSK3β; glycogen synthase kinase; SREBP-1c; sterol reg
Honokiol activates the LKB1-AMPK signaling pathway and attenuates the lipid accumulation in hepatocytes
Keywords: ACC; acetyl-CoA carboxylase; AMPK; AMP-activated protein kinase; ATGL; adipose triglyceride lipase; CaMKK; calcium/calmodulin-dependent protein kinase kinase; FAS; fatty acid synthase; FFA; free fatty acid; HFD; high fat diet; Hon; honokiol; LKB1; liver k
Effect of low carbohydrate high protein (LCHP) diet on lipid metabolism, liver and kidney function in rats
Keywords: Low carbohydrate high protein (LCHP) diet; Lipid metabolism; Kidney function; Wistar rats; ALT; alanine transaminase; AST; aspartate transaminase; BW; body weight; CVD's; cardio-vascular diseases; FAS; fatty acid synthase; HDL; high density lipoprotein; L
The liver-selective NO donor, V-PYRRO/NO, protects against liver steatosis and improves postprandial glucose tolerance in mice fed high fat diet
Keywords: Nitric oxide; Hepatoprotection; Liver steatosis; Glucose tolerance; Fatty acid metabolism; ABCA1; ATP-binding cassette transporter family member 1; ACC; native isoform acetyl-CoA carboxylase; Akt; serine/threonine-protein kinase; ALT; alanine aminotransfe
The local corticotropin-releasing hormone receptor 2 signalling pathway partly mediates hypoxia-induced increases in lipolysis via the cAMP-protein kinase A signalling pathway in white adipose tissue
Keywords: Hypoxia; Corticotropin-releasing hormone receptor 2; White adipose tissue; Lipolysis; CRHR2; corticotrophin-releasing hormone receptor type 2; Ucn2; urocortin 2; Ucn3; urocortin 3; WAT; white adipose tissue; BAT; brown adipose tissue; PKA; protein kinase
Identification of a novel partial agonist of liver X receptor α (LXRα) via screening
Keywords: ABC; ATP-binding cassette; ApoE; apolipoprotein E; DRIP205; vitamin D receptor-interacting protein 205; FAS; fatty acid synthase; GAPDH; glyceraldehyde-phosphate dehydrogenase; HDL; high-density lipoprotein; LBD; ligand-binding domain; LXR; liver X recept
Accumulation of lipids and oxidatively damaged DNA in hepatocytes exposed to particles
Keywords: ABCG5; ATP-binding cassette, sub-family G (WHITE), member 5; ABCG8; ATP-binding cassette, sub-family G (WHITE), member 8; CB; carbon black; DEP; diesel exhaust particles; FASN; fatty acid synthase; FFA; free fatty acids; FPG; formamidopyrimidine DNA glyco
LXR-α antagonist meso-dihydroguaiaretic acid attenuates high-fat diet-induced nonalcoholic fatty liver
Keywords: ABCA1, ABCG1; ATP-binding cassette transporter A1 or G1; AMPK; AMP-activated protein kinase; ACC; acetyl-coenzyme A carboxylase; FAS; fatty acid synthase; HDL; high density lipoprotein; HFD; high fat diet; LBD; ligand binding domain; LXR; liver X receptor
Expression of genes associated with cholesterol and lipid metabolism identified as a novel pathway in the early pathogenesis of Mycobacterium avium subspecies paratuberculosis-infection in cattle
Keywords: 24 DHCR; Ca+; CD38; cholesterol; GIMAP; GNLY; Johne's disease; LDLR; Mycobacterium avium subsp. paratuberculosis; SCD-1
Effects of fisetin supplementation on hepatic lipogenesis and glucose metabolism in Sprague-Dawley rats fed on a high fat diet
Keywords: PPARγ; peroxisome proliferator-activated receptor gamma; SREBP-1c; sterol regulatory element binding transcription factor 1c; SCD-1; stearoyl-Coenzyme A desaturase 1; ACC; acetyl-CoA carboxylase; FAS; fatty acid synthase; ATPCL; ATP citrate lyase; G6Pase
Adiponectin activates the AMPK signaling pathway to regulate lipid metabolism in bovine hepatocytes
Keywords: Ad; adiponectin; NEB; negative energy balance; AdipoR1; adiponectin receptor 1; AdipoR2; adiponectin receptor 2; AMPK; AMP-activated protein kinase; PPARα; peroxisome proliferator-activated receptor α; SREBP-1c; sterol regulatory element-binding protein
Increased dietary fat contributes to dysregulation of the LKB1/AMPK pathway and increased damage in a mouse model of early-stage ethanol-mediated steatosis
Keywords: ACC; acetyl CoA carboxylase; ALD; alcoholic liver disease; ALT; alanine aminotransferase; AMPK; AMP-activated protein kinase; ACLY; ATP citrate lyase; ChREBP; carbohydrate response element binding protein; CYP2E1; cytochrome p450 2E1; ELOVL5; fatty acid e
Polyphenol-rich black chokeberry (Aronia melanocarpa) extract regulates the expression of genes critical for intestinal cholesterol flux in Caco-2 cells
Keywords: ACOX-1; acyl-CoA oxidase 1; ABCA1; ATP binding cassette transporter A1; ABCG5/8; ATP binding cassette transporter G5/8; CVD; cardiovascular disease; CPT-1α; carnitine palmitoyltransferase 1α; FAS; fatty acid synthase; HMGR; 3-hydroxy-3-methylglutaryl co
Ethyl 2,4,6-trihydroxybenzoate is an agonistic ligand for liver X receptor that induces cholesterol efflux from macrophages without affecting lipid accumulation in HepG2 cells
Keywords: ABC; ATP-binding cassette transporter; FAS; fatty acid synthase; HDL; high-density lipoprotein; LBD; ligand-binding domain; LDL; low-density lipoprotein; LXR; liver X receptor; NPC1L1; Niemann-Pick C1 Like 1; SCD-1; stearoyl-CoA desaturase 1; SPR; surface
Herbal medicines for the prevention of alcoholic liver disease: A review
Keywords: ACC; acetyl-CoA carboxylase; ACLY; ATP-citrate lyase; ALD; alcoholic liver disease; ALP; alkaline phosphatase; ALT; alanine aminotransferase; AMPK; AMP-activated protein kinase; AST; aspartate aminotransferase; AOX; acyl-CoA oxidase; CAT; catalase; COX-2;
Progestin modulates the lipid profile and sensitivity of breast cancer cells to docetaxel
Keywords: Progestin; Metabolism; Breast cancer; SCD-1; Lipid droplets; Docetaxel
N-Benzylimidazole carboxamides as potent, orally active stearoylCoA desaturase-1 inhibitors
Keywords: Stearoyl-CoA desaturase; Obesity; SCD-1
Ghrelin neutralization during fasting-refeeding cycle impairs the recuperation of body weight and alters hepatic energy metabolism
Keywords: 6PGDH; 6-phosphogluconate dehydrogenase; ACCα; acetyl-CoA carboxylase alpha; ACL; ATP citrate lyase; AKT; total serine/threonine kinase protein kinase B; AMPKα; 5â²AMP-activated protein kinase alpha; CPT1A; liver isoform of carnitine palmitoyltransfera
Fatty liver: Role of inflammation and fatty acid nutrition
Keywords: NEFA; nonesterified fatty acid; HSL; hormone sensitive lipase; LPL; lipoprotein lipase; VLDL; very-low density lipoprotein; n-3 PUFA; omega - 3 polyunsaturated fatty acid; SREBP-1c; sterol regulatory element binding protein-1c; ACC; acetyl CoA carboxy
Relationships between serum fatty acid composition and multiple markers of inflammation and endothelial function in an elderly population
Keywords: Fatty acids; Inflammation; Endothelial function; SCD-1; C-reactive protein; Adhesion molecules;
Hepatic Fatty Acid Transporter Cd36 Is a Common Target of LXR, PXR, and PPARγ in Promoting Steatosis
Keywords: Acc-1; acetyl CoA carboxylase 1; DTg; double transgenic; Fae; long-chain free fatty acid elongase; Fas; fatty acid synthase; FFA; free fatty acid; HA; hemagglutinin; LXR; liver X receptor; PCN; pregnenolone-16α-carbonitrile; PPAR; peroxisome proliferator
Euonymus alatus prevents the hyperglycemia and hyperlipidemia induced by high-fat diet in ICR mice
Keywords: ACOx; acylCoA oxidase; AUC; area under the curve; CD36; fatty acid transporter CD36; CPN; cyclophilin; CPT-la; carnitine palmitoyl transferase; DIG; digoxigenin; EA; Euonymus alatus; ELISA; enzyme-linked immunosorbent assay; FABP; fatty acids-binding and