کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3297180 | 1209881 | 2008 | 13 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Hepatic Fatty Acid Transporter Cd36 Is a Common Target of LXR, PXR, and PPARγ in Promoting Steatosis
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کلمات کلیدی
FASFFAacetyl CoA carboxylase 1DTGSCD-1PPARFAEPCNACC-1PXRLXRSREBPpregnenolone-16α-carbonitrile - pregnenolone-16α-کربناتریلFree fatty acid - اسید چرب آزادfatty acid synthase - اسید چرب سنتازTransgenic - تراریختهdouble transgenic - دوگانه ترانس ژنیکhemagglutinin - هماگلوتینینSterol regulatory element-binding protein - پروتئین اتصال دهنده پروتئین Sterol Regulatoryliver X receptor - کبد X گیرندهperoxisome proliferator-activated receptor - گیرنده فعال فعال پروکسیومPregnane X receptor - گیرنده پیش گران X
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
بیماریهای گوارشی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Hepatic Fatty Acid Transporter Cd36 Is a Common Target of LXR, PXR, and PPARγ in Promoting Steatosis Hepatic Fatty Acid Transporter Cd36 Is a Common Target of LXR, PXR, and PPARγ in Promoting Steatosis](/preview/png/3297180.png)
چکیده انگلیسی
Background & Aims: Liver X receptor (LXR) is known to promote hepatic lipogenesis by activating the lipogenic transcriptional factor sterol regulatory element-binding protein (Srebp). Pregnane X receptor (PXR), a previously known “xenobiotic receptor,” could mediate a Srebp-independent lipogenic pathway by activating the free fatty acid uptake transporter Cd36. The goal of this study is to investigate further the role of Cd36 in hepatic steatosis. Methods: Wild-type, LXR transgenic, PXR transgenic, and Cd36 null mice were used to study the regulation of Cd36 and other hepatic lipogenic genes and the implication of this regulation in hepatic steatosis. Promoter sequences of Cd36 and peroxisome proliferator-activated receptor (PPAR) γ were cloned, and their respective regulation by LXR and PXR was investigated by combinations of receptor-DNA binding and reporter gene assays. Results: We showed that genetic (transgene) or pharmacologic (ligands) activation of LXR induced Cd36. Promoter analysis established Cd36 as a novel transcription target of LXRα. Moreover, the hepatic steatosis induced by LXR agonists was largely abolished in Cd36 null mice. We also showed that PPARγ, a positive regulator of Cd36, is a transcriptional target of PXR, suggesting that PXR can regulate Cd36 directly or through its activation of PPARγ. Interestingly, both LXR-mediated Cd36 regulation and PXR-mediated PPARγ regulation are liver specific. Conclusions: We conclude that Cd36 is a shared target of LXR, PXR, and PPARγ. The network of CD36 regulation by LXR, PXR, and PPARγ establishes this free fatty acid transporter as a common target of orphan nuclear receptors in their mediation of lipid homeostasis.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Gastroenterology - Volume 134, Issue 2, February 2008, Pages 556-567.e1
Journal: Gastroenterology - Volume 134, Issue 2, February 2008, Pages 556-567.e1
نویسندگان
Jie Zhou, Maria Febbraio, Taira Wada, Yonggong Zhai, Ramalinga Kuruba, Jinhan He, Jung Hoon Lee, Shaheen Khadem, Songrong Ren, Song Li, Roy L. Silverstein, Wen Xie,