Keywords: گیرنده پیش گران X; 1°BAs; primary bile acids; 2°BAs; secondary bile acids; BA; bile acid; CDCA; chenodeoxycholic acid; CA; cholic acid; DEX; dexamethasone; GR; glucocorticoid receptor; MCA; muricholic acid; PXR; pregnaneâXâreceptor; ΣBAs; total bile acids; T-BAs; tau
مقالات ISI گیرنده پیش گران X (ترجمه نشده)
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Keywords: گیرنده پیش گران X; 11βHSD; 11β-Hydroxysteroid dehydrogenase; ABC; ATP-binding cassette; AhR; aryl hydrocarbon receptor; ARNT; aryl hydrocarbon receptor nuclear translocator; BCRP; breast cancer resistance protein; CAR; constitutive androstane receptor; CYP; cytochrome P45
Keywords: گیرنده پیش گران X; AHR; aryl hydrocarbon receptor; AR; androgen receptor; As; arsenic; BaP; benzo[a]pyrene; CASP; caspase; CRISPR; clustered regularly interspaced short palindromic repeats; CTD; Comparative Toxicogenomics Database; CYP; cytochrome P450; CXCL8; chemokine (C-
Keywords: گیرنده پیش گران X; AHR; aryl hydrocarbon receptor; ALD; alcoholic liver disease; BAs; bile acids; CAR; constitutive androstane receptor; CARM1; coactivator associated arginine methyltransferases 1; CBP/P300; CREB-binding protein/p300; CYP27A1/Cyp27a1; sterol 27α-hydroxylas
Keywords: گیرنده پیش گران X; ASBT; apical sodium-dependent bile acid transporter; ASDs; amorphous solid dispersions; BACS; bile acid-CoA synthase; BAT; bile acid-amino acid transferase; BCS; biopharmaceutics classification system; BSH; bile salt hydrolase; C4; 7α-hydroxy-4-cholesten
Keywords: گیرنده پیش گران X; Oxysterols; Cancer; Polymorphism; Risk; Genetics; Cholesterol; 25(OH)D; 25-hydroxyvitamin D; ABC; ATP-binding cassette; AEBS; antiestrogen-binding site; BC; breast cancer; BCR; biochemical recurrence; CETP; cholesteryl ester transfer protein; CH25H; chole
Keywords: گیرنده پیش گران X; Cytochrome P450; Liver; Gene expression; Sex; Age; Drug metabolism; BChE; butyrylcholinesterase; CYP; cytochrome P450; GST; glutathione S-transferase; PCR; polymerase chain reaction; PXR; pregnane X receptor; RT-PCR; reverse transcriptase PCR; SULT; sulfo
Keywords: گیرنده پیش گران X; PXR; Pregnane X receptor; LPS; Lipopolysaccharide; TLR4; Toll-like receptor 4; DMETs; Drug metabolizing enzymes and transporters; CES; Carboxylesterase; CYP; Cytochrome P450; SN-38; 7-Ethyl-10-hydroxycamptothecin; SN-38G; SN-38 glucuronide; UGT1A1; Uridin
Keywords: گیرنده پیش گران X; Hepatic injury; Flavonoids; Hepatoprotection; Mechanisms; Traditional Chinese medicinal (TCM) herbs; ATGL; adipose triglyceride lipase; D-GaIN; d-galactosamine; FLIP; FLICE inhibitory protein; HA; hyaluronic acid; LDH; lactate dehydrogenase; LDL-C; low-de
Keywords: گیرنده پیش گران X; Benchmark dose modeling; DNA methylation; LINE-1; miRNA; Metabolomics; Hepatotoxicants; Dose-response; Ahr; Aryl Hydrocarbon receptor; BA; Bile Acid; BMD; Benchmark Dose; BrdU; Bromodeoxyuridine; CAR; Constitutive Androgen Receptor; CF; Clofibrate; ChIP;
Keywords: گیرنده پیش گران X; transporters; metabolism; drug-metabolizing enzymes; pharmacokinetics; hepatic transport; hepatic metabolism; organic anion-transporting polypeptide transporters; ALT; alanine aminotransferase; AST; aspartate aminotransferase; ATP; adenosine triphosphate;
Keywords: گیرنده پیش گران X; Intracellular drug concentration; Pharmacodynamics; OCT; MATE; PMAT; Drug transporter; ABC; ATP-binding cassette; ACC; acetyl-CoA carboxylase; AMP; adenosine monophosphate; AMPK; AMP-activated protein kinase; AUC; area under the concentration time curve;
Keywords: گیرنده پیش گران X; ABCB; ATP-binding cassette sub-family B; Apo; apolipoprotein; ASBT; apical sodium dependent bile acid transporter; BDL; bile duct ligation; BSEP; bile salt export pump; CA; cholic acid; CDCA; chenodeoxycholic acid; C/EBP; CCAAT-enhancer-binding protein; C
Keywords: گیرنده پیش گران X; Ciona intestinalis; Botryllus schlosseri; Pregnane X receptor; Saccharomyces cerevisiae; Marine biotoxins; Bioassay; AD; activation domain; AF-2; transcription activation function domain; BsVDR/PXRα; Botryllus schlosseri VDR/PXR orthologue α; BPA; bisph
Keywords: گیرنده پیش گران X; AR (NR3C4); androgen receptor; CAR (NR1I3); constitutive androstane receptor; COUP-TF (NR2F); chicken ovalbumin upstream promoter transcription factor; DAF-12; (abnormal) dauer formation (NR)-12; DAX-1 (NR0B1); dosage-sensitive sex reversal, adrenal hypop
Keywords: گیرنده پیش گران X; AR; androgen receptor; CAR; constitutive androstane receptor; DBD; DNA-binding domain; EDC; endocrine disrupting chemical; ER; estrogen receptor; FXR; farnesoid X receptor; GR; glucocorticoid receptor; HRE; hormone responsive elements; LBD; ligand-binding
Keywords: گیرنده پیش گران X; CYP; cytochrome P-450; GSH-transferase; glutathione-S-transferase; UDP-glucuronosyltransferase; uridine 5â²-diphospho-glucuronosyltransferase; EGb761®; Ginkgo biloba extract, CAS 122933-57-7; AhR; aryl hydrocarbon receptor; PXR; pregnane X receptor; CAR
Keywords: گیرنده پیش گران X; LPS; lipopolysaccharide; IL-6; interleukin-6; DMEs; drug-metabolizing enzymes; Ces (mouse) or CES (human); carboxylesterases; CYP; cytochrome P450; PXR; pregnane X receptor; CAR; constitutive androstane receptor; RXR; retinoid X receptor; NFκB; nuclear f
Keywords: گیرنده پیش گران X; AhR; aryl hydrocarbon receptor; ARE; antioxidant response element; BT; black tea; CYP; cytochrome P450; DME; drug-metabolizing enzymes; DR4; direct repeat with 4Â bp spacer; DRE; dioxin response elements; GT; green tea beverage; EC; epicatechin; EGC; epig
Keywords: گیرنده پیش گران X; BTBPE; 1,2-bis(2,4,6-tribromophenoxy)ethane; EDC; endocrine disrupting chemicals; HBCD; hexabromocyclododecane; HPT; hypothalamus-pituitary-thyroid; ID, ID1, ID2, ID3; iodothyronine deiodinase, type 1, type 2, type 3; mono; monodeiodination; OH-PBDE;
Keywords: گیرنده پیش گران X; ABC; ATP-binding cassette; AE2 (SLC4A2); anion exchanger 2; ALT; alanine aminotransferase; AMPK; AMP-activated protein kinase; ALP; alkaline phosphatase; ASBT (SLC10A2); apical sodium-dependent bile acid transporter; ASCOM; activating signal cointegrator-
Keywords: گیرنده پیش گران X; Cholesterol; Oxysterol; CYP46A1; CYP27A1; CYP3A4; CYP39A1; CYP7B1; CH25H; Cholesterol 7α-hydroxylase; Sterol 27-hydroxylase; Cholesterol 24-hydroxylase; Cholesterol 25-hydroxylase; Oxysterol 7α-hydroxylase; 24-hydroxycholesterol 7α-hydroxylase; Epigene
Keywords: گیرنده پیش گران X; MS; mass spectrometry; UPLC; ultraperformance liquid chromatography; UPLC-ESI-QTOFMS; UPLC-electrospray ionization-quadrupole time-of-flight MS; LCMS; liquid chromatography-mass spectrometry; GCMS; gas chromatography-mass spectrometry; NMR; nuclea
Effects of carbamazepine on the P-gp and CYP3A expression correlated with PXR or NF-κB activity in the bEnd.3 cells
Keywords: گیرنده پیش گران X; Drug-resistant epilepsy; Carbamazepine; Pregnane X receptor; Nuclear factor kappa B; P-glycoprotein; Cytochrome P450; Brain microvascular endothelial cells;
Drechmerin H, a novel 1(2), 2(18)-diseco indole diterpenoid from the fungus Drechmeria sp. as a natural agonist of human pregnane X receptor
Keywords: گیرنده پیش گران X; Drechmeria sp.; Indole diterpenoid; Agonistic effect; Pregnane X receptor; Molecular docking;
A CYP2B6-humanized mouse model and its potential applications
Keywords: گیرنده پیش گران X; CYP2B6; Liver; Drug metabolism; Xenobiotic toxicity; Knockout mice; Humanized mice; WT; wild-type; CYPs; cytochromes P450; CAR; constitutive androstane receptor; PXR; pregnane X receptor; GR; glucocorticoid receptor; PB; phenobarbital; and DEX; dexamethas
Comparison of the hepatic and thyroid gland effects of sodium phenobarbital in wild type and constitutive androstane receptor (CAR) knockout rats and pregnenolone-16α-carbonitrile in wild type and pregnane X receptor (PXR) knockout rats
Keywords: گیرنده پیش گران X; Sodium phenobarbital; Pregnenolone-16α-carbonitrile; Constitutive androstane receptor; Pregnane X receptor; Receptor knockout rats; Cytochrome P450;
Shikonin upregulates the expression of drug-metabolizing enzymes and drug transporters in primary rat hepatocytes
Keywords: گیرنده پیش گران X; AhR; aryl hydrocarbon receptor; AP1; activating protein 1; ARE; antioxidant-response element; CAR; constitutive androstane receptor; CYP; cytochrome P450; DREs; dioxin-responsive elements; EMSA; electromobility gel shift assay; FBS; fetal bovine serum; GS
Identification of bicyclic hexafluoroisopropyl alcohol sulfonamides as retinoic acid receptor-related orphan receptor gamma (RORγ/RORc) inverse agonists. Employing structure-based drug design to improve pregnane X receptor (PXR) selectivity
Keywords: گیرنده پیش گران X; ROR; retinoic acid-related orphan receptor; PXR; pregnane X receptor; LXR; liver X receptor; IBD; inflammatory bowel disease; RA; rheumatoid arthritis; MS; multiple sclerosis;
Significance of A-to-I RNA editing of transcripts modulating pharmacokinetics and pharmacodynamics
Keywords: گیرنده پیش گران X; ABC; ATP-binding cassette transporter; ADAR; adenosine deaminase acting on RNA; ADH; alcohol dehydrogenase; AhR; aryl hydrocarbon receptor; AKR; aldo-keto reductase; ALS; amyotrophic lateral sclerosis; AZIN1; antizyme inhibitor 1; AMPA; α-amino-3-hydroxy
Essential oils of culinary herbs and spices activate PXR and induce CYP3A4 in human intestinal and hepatic in vitro models
Keywords: گیرنده پیش گران X; AhR; aryl hydrocarbon receptor; EO; essential oil; EtOH; ethanol; CAR; constitutive androstane receptor; GR; glucocorticoid receptor; PXR; pregnane X receptor; RIF; rifampicin; VDR; vitamin D receptor; Food-drug interactions; Human hepatocytes; Essential
Development of novel silanol-based human pregnane X receptor (PXR) agonists with improved receptor selectivity
Keywords: گیرنده پیش گران X; Pregnane X receptor; Nuclear receptor; Silanol; Sila-substitution; C/Si-exchange; Alcohol/silanol-exchange; T0901317;
Comparison of the effects of sodium phenobarbital in wild type and humanized constitutive androstane receptor (CAR)/pregnane X receptor (PXR) mice and in cultured mouse, rat and human hepatocytes
Keywords: گیرنده پیش گران X; Sodium phenobarbital; Constitutive androstane receptor; Pregnane X receptor; hCAR/hPXR mice; Cultured hepatocytes; Replicative DNA synthesis;
PDZ domain containing protein 1 (PDZK1), a modulator of membrane proteins, is regulated by the nuclear receptor THRβ
Keywords: گیرنده پیش گران X; Thyroid hormones; Scaffold protein; PDZ-domain; Gene regulation; Thyroid hormone receptors; 5-HT2A; Serotonin 2A receptor; ABC; ATP-binding cassette transporter; AhR; Transcription factor aryl hydrocarbon receptor; BCRP; Breast cancer resistance protein;
ETS-1 induces Sorafenib-resistance in hepatocellular carcinoma cells via regulating transcription factor activity of PXR
Keywords: گیرنده پیش گران X; Hepatocellular carcinoma; E26 transformation specific sequence 1; Pregnane X receptor; Molecular targeted agents; Sorafenib resistance;
Effect-based trigger values for in vitro and in vivo bioassays performed on surface water extracts supporting the environmental quality standards (EQS) of the European Water Framework Directive
Keywords: گیرنده پیش گران X; AA-EQS; average annual environmental quality standard; ACR; acute-to-chronic ratio; AhR; arylhydrocarbon receptor; AR; androgen receptor; AWTP; advanced water treatment plant; BEQ; bioanalytical equivalent concentration; DWTP; drinking water treatment pla
Inhibitory effect of PXR on ammonia-induced hepatocyte autophagy via P53
Keywords: گیرنده پیش گران X; Hepatocyte; Autophagy; Ammonia; Pregnane X receptor;
Ubiquitination/sumoylation: An alternative pathway to modify gene regulation directed by xenosensors
Keywords: گیرنده پیش گران X; Epigenetic regulation; Post-translational modifications; Nuclear receptors; Xenobiotics metabolism; AHR; aryl hydrocarbon receptor; AHRR; aryl hydrocarbon receptor repressor; ARNT; aryl hydrocarbon receptor nuclear translocator; CAR; constitutive androsta
Combination of CYP2C19 genotype with non-genetic factors evoking phenoconversion improves phenotype prediction
Keywords: گیرنده پیش گران X; CAR; constitutive androstane receptor; CI; confidence interval; CYP; cytochrome P450; EM; extensive metabolizer; GAPDH; glyceraldehyde 3-phosphate dehydrogenase; GR; glucocorticoid receptor; IM; intermediate metabolizer; PCR; polymerase chain reaction; PM
The longevity gene INDY (I'm Not Dead Yet) in metabolic control: Potential as pharmacological target
Keywords: گیرنده پیش گران X; Aak2; 5â²AMP-activated protein kinase catalytic subunit alpha-2; ACC; acetyl CoA carboxylase; Acly; ATP citrate lyase; Adipo-IR; adipose tissue insulin resistance index; ADME; absorption, distribution, metabolism, excretion; AGA; appropriate-for-gestatio
Characterization of CYP2C Induction in Cryopreserved Human Hepatocytes and Its Application in the Prediction of the Clinical Consequences of the Induction
Keywords: گیرنده پیش گران X; cytochrome P450; mathematical models; hepatocytes; drug-drug interaction; induction; CAR; constitutive androstane receptor; CITIO; 6-(4-clorophenyl) imidazo[2,1-b][1,3]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime; P450; cytochrome P450; DDI; drug-d
Effect of amyloid beta on ATP-binding cassette transporter expression and activity in porcine brain microvascular endothelial cells
Keywords: گیرنده پیش گران X; ABCB1; ABCG2; ABCC5; Nuclear receptors; Amyloid-β; Alzheimer's disease; Porcine brain endothelial cells; ABC; ATP-binding cassette; Aβ(1-42); amyloid-β (1-42); BBB; blood-brain barrier; CAR; constitutive androstane receptor; CAPS; 3-(Cyclohexylam
Nuclear receptor FXR, bile acids and liver damage: Introducing the progressive familial intrahepatic cholestasis with FXR mutations
Keywords: گیرنده پیش گران X; NR; nuclear receptor; FXR; farnesoid X receptor; RXR; retinoid X receptor; PXR; pregnane X receptor; VDR; Vitamin D receptor; TGR5; G protein-coupled bile acid receptor; Lrh1; liver receptor homolog 1; Mdr; multidrug resistance protein; Abcb4; ATP Bindi
Epidermal Overexpression of Xenobiotic Receptor PXR Impairs the Epidermal Barrier and Triggers Th2 Immune Response
Keywords: گیرنده پیش گران X; AD; atopic dermatitis; CYP450; cytochrome P450; DC; dendritic cell; ILC; innate lymphoid cell; ILCs2; type 2 innate lymphoid cells; K14; keratin 14; PXR; pregnane X receptor; TEWL; transepidermal water loss; Th; T helper; TSLP; thymic stromal lymphopoiete
E4bp4 regulates carboxylesterase 2 enzymes through repression of the nuclear receptor Rev-erbα in mice
Keywords: گیرنده پیش گران X; bZip; the basic leucine zipper; CAR; constitutive androstane receptor; Ces/CES; mouse and human carboxylesterases; ChIP; chromatin immunoprecipitation assay; Co-IP; co-immunoprecipitation; CYP7A1; cholesterol 7alpha-hydroxylase; DMEM; Dulbecco's modifie
Biotechnology Challenges to In Vitro Maturation of Hepatic Stem Cells
Keywords: گیرنده پیش گران X; Liver Development; Differentiation; Hepatocyte; Culture; CRISPR; clustered regularly interspaced short palindromic repeats; CYP; cytochrome P450; 3D; 3-dimensional; DNMTi; DNA methylation inhibitor; ECM; extracellular matrix; ESC; embryonic stem cell; ES-
In vitro effect of mPEG2k-PCLx micelles on rat liver cytochrome P450 enzymes
Keywords: گیرنده پیش گران X; Ahr; aryl hydrocarbon receptor; Car; constitutive androstane receptor; Pxr; pregnane X receptor; mPEG2k-PCLx micelles; Cytochrome P450 enzymes; Inhibition; Induction; Rat liver microsomes; Primary rat hepatocytes;
Effects of pyrethroid pesticide cis-bifenthrin on lipogenesis in hepatic cell line
Keywords: گیرنده پیش گران X; Pyrethroids; Lipid metabolism; cis-bifenthrin; Pregnane X receptor; Enantioselective;
Pregnane X receptor mediates sorafenib resistance in advanced hepatocellular carcinoma
Keywords: گیرنده پیش گران X; Hepatocellular carcinoma; Pregnane X receptor; Multi-drug resistance; Sorafenib; Metabolism and clearance;
Human-based systems: Mechanistic NASH modelling just around the corner?
Keywords: گیرنده پیش گران X; Elafibranor (PubChem CID: 9864881); Obeticholic acid (PubChem CID: 447715); Pioglitazone (PubChem CID: 4829); Rosiglitazone (PubChem CID: 77999); Fenofibrate (PubChem CID: 3339); Serine (PubChem CID: 5951); ACC1; acetyl-coenzyme A carboxylase 1; AdipoR; a