کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9010204 | 1124104 | 2005 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Euonymus alatus prevents the hyperglycemia and hyperlipidemia induced by high-fat diet in ICR mice
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کلمات کلیدی
T1DMGLUT4Euonymus alatusCD36PPARγHOMA-IRHFDOGTTT2DMGAPDHFFANEFAFASACOXFABPCPNPPAR-γGPATSCD-1NAFLDAUC - AUCTZDs - TZD هاOral glucose tolerance test - آزمون تحمل گلوکز خوراکیFree fatty acid - اسید چرب آزادfatty acid synthase - اسید چرب سنتازNon-esterified fatty acid - اسید چرب غیر استرادیلیDiabetes - بیماری قندnon-alcoholic fatty liver disease - بیماری کبدی چربی غیر الکلیELISA - تست الیزاEnzyme-linked immunosorbent assay - تست الیزاThiazolidinedione - تیازولیدیدئونglucose transporter 4 - حمل کننده گلوکز 4type 1 diabetes mellitus - دیابت نوع 1Type 2 diabetes mellitus - دیابت نوع دوdigoxigenin - دیگوکسین ژنhigh-fat diet - رژیم غذایی با چربی بالاregular diet - رژیم منظمcyclophilin - سیکلوفیلینDIG - شماAnti-hyperglycemic activity - فعالیت ضد هیپرگلیسمیMetformin - متفورمینarea under the curve - منطقه تحت منحنیSterol regulatory element binding protein 1 - پروتئین اتصال دهنده عصاره استریل 1carnitine palmitoyl transferase - کاردینیت پالمیتویل ترانسفرازtotal cholesterol - کلسترول تامglycerol-3-phosphate acyltransferase - گلیسرول 3-فسفات آتیل ترانسفرازglyceraldehyde 3-phosphate dehydrogenase - گلیسرولیدید 3-فسفات دهیدروژنازPeroxisome proliferator activated receptor gamma - گیرنده گیرنده فعال فعال پروکسیزوم فعال است
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
داروشناسی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Euonymus alatus (EA), known as a Gui Jeon Wu in China, has been used as a folk medicine for regulating blood circulation, relieving pain, eliminating blood clot, and treating dysmenorrhea in Asian countries. Although EA has anecdotally ascertained to show the anti-hyperglycemic activity by enhancing insulin secretion, there is no sufficient experimental evidence for anti-hyperglycemic activity of EA. The purpose of this study was to investigate the preventive effect of 50% ethanol extract of EA in high-fat diet-induced hyperglycemic and hyperlipidemic ICR mice. At 6 week old, the ICR mice were randomly divided into five groups; two control and three treatment groups. The control mice was to receive either a regular diet (RD) or high-fat diet (HFD), and the treatment groups were fed a high-fat diet with either 350, 700 mg/kg of EA (EA350 and EA700) or 250 mg/kg of metformin (MET250) for a 10-week period. EA not only reduced body weight in a dose dependent manner, but also corrected associated hyperinsulinemia and hyperlipidemia. EA exerted beneficial effects on glucose and lipid homeostasis in diabetes that are not secondary to its ability to decrease food intake but its specific effects on hepatic lipogenesis related genes (SREBPla, FAS, GAPT) and PPAR-γ gene expression in periepididymal fat. Taken together, the combined effect of EA to reduce plasma glucose and lipid levels, and reduce the deposition of triglyceride in the liver are indicative of a marked improvement in obesity-related diabetes and non-alcoholic fatty liver disease.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Ethnopharmacology - Volume 102, Issue 3, 1 December 2005, Pages 326-335
Journal: Journal of Ethnopharmacology - Volume 102, Issue 3, 1 December 2005, Pages 326-335
نویسندگان
Sang Hyun Park, Sung Kwon Ko, Sung Hyun Chung,