Effects of fisetin supplementation on hepatic lipogenesis and glucose metabolism in Sprague-Dawley rats fed on a high fat diet

► Selective hepatic insulin resistance is the hallmark of obesity. ► Fisetin reduces hepatic TG accumulation and circulating glucose. ► Fisetin modulates genes in hepatic lipogenesis and gluconeogenesis. ► Fisetin enhances GLUT4 expression in adipose tissue and 3T3-L1 adipocytes. ► Fisetin alleviates selective hepatic insulin resistance.