کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5849012 | 1130688 | 2012 | 6 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Effects of isoflurane inhalation on the male reproductive system in rats Effects of isoflurane inhalation on the male reproductive system in rats](/preview/png/5849012.png)
The 15-day intact adult male assay was used to evaluate effects of isoflurane on the testes and sexual hormones. Forty adult male Sprague-Dawley rats were divided into five groups exposed to air containing 0, 50, 300, 1800 or 10,800Â ppm isoflurane. After the treatments, serum was collected for the hormones assay. The right testis was to be used for daily sperm production. The left testis was processed for histopathology and electron microscopy observation. Daily sperm productions were significantly decreased at doses of 300, 1800 and 10,800Â ppm. Impaired seminiferous tubules were noted at doses of 300, 1800 and 10,800Â ppm. Ultrastructural changes included nucleus agglutination of spermatocytes, big lipid drops and autophagosome in cytoplasm. The serum follicle-stimulating hormone and testosterone concentrations reduced significantly at doses of 1800 and 10,800Â ppm. Isoflurane induced impairments of seminiferous tubules and spermatogenesis. The testicular damages caused by isoflurane can be related to the imbalances in the sexual hormones.
⺠The 15-day intact adult male assay was used. ⺠It was to evaluate effects of isofurane on testes and sexual hormones. ⺠Isofurane impaired seminiferous tubules and spermatogenesis. ⺠The serum FSH and testosterone concentrations reduced significantly. ⺠The testicular damages are related to the sexual hormones imbalance.
Journal: Environmental Toxicology and Pharmacology - Volume 34, Issue 3, November 2012, Pages 688-693