کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5849033 | 1130688 | 2012 | 8 صفحه PDF | دانلود رایگان |
Glyphosate (GLP), the active ingredient of many weed killing formulations, is a broad spectrum herbicide compound. Wistar rats were exposed during 30 or 90 days to the highest level (0.7Â mg/L) of GLP allowed in water for human consumption (US EPA, 2011) and a 10-fold higher concentration (7Â mg/L). The low levels of exposure to the herbicide did not produce histomorphological changes. The production of TBARS was similar or tended to be lower compared to control animals not exposed to the herbicide. In rats exposed to GLP, increased levels of reduced glutathione (GSH) and enhanced glutathione peroxidase (GPx) activity may act as a protective mechanism against possible detrimental effects of the herbicide. Overall, this work showed certain biochemical modifications, even at 3-20-fold lower doses of GLP than the oral reference dose of 2Â mg/kg/day (US EPA, 1993). The toxicological significance of these findings remains to be clarified.
⺠Non target species may be exposed to environmental traces of the herbicide glyphosate. ⺠Glyphosate exposure increased the levels of reduced glutathione in rat liver. ⺠Glutathione peroxidase activities also increased in liver, kidney and gut mucosa. ⺠These changes may protect the organism against detrimental effects of the herbicide.
Journal: Environmental Toxicology and Pharmacology - Volume 34, Issue 3, November 2012, Pages 811-818