Protective effect of dendrodoine analog, an aminothiazole derivative against X-radiation induced hepatocellular damage in mice

This study evaluated the radioprotective effect of dendrodoine analog (DA) against radiation-induced damage in the liver of mice. The study was divided into two phases; in the first phase, the effective concentration of DA was fixed by performing a survival study. In the second phase, the fixed effective concentration of DA was orally administered to mice to evaluate its radioprotective efficacy by performing various assays. The results indicated that the radiation-induced decrease in the activities of antioxidant enzymes, increase in thiobarbituric acid reactive substances (TBARS) and comet parameters were altered by pre-administration with the effective concentration of DA which restored the antioxidant status to near normal and decreased the level of the TBARS and comet parameters. The histopathological examinations further confirmed the hepatoprotective effect of DA in mice. Thus, the current study showed DA to be an effective radioprotector against radiation induced damage in the liver of mice.

► Exposure to radiation decreased the activities of antioxidant enzymes in mice. ► Further radiation increased the levels of TBARS and comet parameters in mice. ► Pre administration with DA restored antioxidant activities in liver of mice. ► DA also decreased the level of TBARS and comet parameters in mice. ► Histopathological examinations of mice liver confirmed the above findings.