کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5849251 | 1561751 | 2016 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
In vitro toxicity assessment of extracts derived from sol-gel coatings on polycarbonate intended to be used in food contact applications
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
FCMPBSMTESFBSTEOSBNCOECDTetraethylorthosilicate - tetraethylorthosilicateMicronucleus assay - آزمایش میکرونوکلئوسEndocrine disruption - اختلالات غدد درون ریزAmes test - تست ایمز minimum essential medium - حداقل حداقل مورد نیازHepG2 cell line - خط سلول HepG2Organization for Economic Co-operation and Development - سازمان همکاری و توسعه اقتصادیfetal bovine serum - سرم جنین گاوbinucleated cell - سلول دو هسته ایInduction factor - عامل القاییExtracts - عصاره هاPhosphate buffered saline - فسفات بافر شورMEM - مامانMethyltriethoxysilane - متیلتروتوکسیسیلانMigration - مهاجرتFood contact materials - مواد تماس با مواد غذاییMicronucleus - میکروسکوپPolycarbonate - پلی کربناتSol–gel coating - پوشش سل ژل
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش تغذیه
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Polycarbonate is a widely used polymer in food contact applications all around the world. However, due to the potential release of Bisphenol A (BPA) during repeated washing cycles, its use becomes compromised as BPA is known for being an endocrine disruptor for rodents. In order to tackle this issue, sol-gel coatings based on organoalkoxysiloxane were developed on PC, to act as a physical barrier. To this end, two sol-gel systems based on tetraethylorthosilicate (TEOS), methyltriethoxysilane (MTES) and 3-glycidyloxypropyltriethoxysilane (GPTES), three common sol-gel precursors, were prepared. The coatings derived from the latter two systems were then studied with regards to their potential toxicity in vitro. Migration tests were performed in food simulants, and the maximal migration was obtained in ethanol 10% (v/v) for one system and in isooctane for the other one. In vitro genotoxicity was assessed with the Ames test (OECD 471) and the micronucleus assay (OECD 487), and no genotoxic effect was observed. Moreover, the estrogenic activity of the extracts was studied with a transcriptional activation assay using transient transfection in human cells; none of the extracts was found estrogenic. These negative in vitro results are highly promising for the future use of these new barrier coating formulations onto food contact materials.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Food and Chemical Toxicology - Volume 93, July 2016, Pages 51-57
Journal: Food and Chemical Toxicology - Volume 93, July 2016, Pages 51-57
نویسندگان
Isabelle Séverin, Krystelle Lionti, Laurence Dahbi, Catherine Loriot, Bérangère Toury, Marie-Christine Chagnon,