کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5849341 | 1561752 | 2016 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Pharmacokinetics of isoflavones from soy infant formula in neonatal and adult rhesus monkeys
ترجمه فارسی عنوان
فارماکوکینتیک ایزوفلاون ها از فرمول نوزاد شیر سویا در میمون های نوزاد و بالغ ریز
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کلمات کلیدی
سویا، جنیستاین، داایدزین، میمون رشت، فارماکوکینتیک، طیف سنجی جرمی، نوزادان،
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش تغذیه
چکیده انگلیسی
Consumption of soy infant formula represents a unique exposure scenario in which developing children ingest a mixture of endocrine-active isoflavones along with a substantial portion of daily nutrition. Genistein and daidzein were administered as glucoside conjugates to neonatal rhesus monkeys in a fortified commercial soy formula at 5, 35, and 70 days after birth. A single gavage dosing with 10Â mg/kg bw genistein and 6Â mg/kg bw daidzein was chosen to represent the upper range of typical daily consumption and to facilitate complete pharmacokinetic measurements for aglycone and total isoflavones and equol. Adult monkeys were also gavaged with the same formula solution at 2.8 and 1.6Â mg/kg bw genistein and daidzein, respectively, and by IV injection with isoflavone aglycones (5.2 and 3.2Â mg/kg bw, respectively) to determine absolute bioavailability. Significant differences in internal exposure were observed between neonatal and adult monkeys, with higher values for dose-adjusted AUC and Cmax of the active aglycone isoflavones in neonates. The magnitude and frequency of equol production by the gut microbiome were also significantly greater in adults. These findings are consistent with immaturity of metabolic and/or physiological systems in developing non-human primates that reduces total clearance of soy isoflavones from the body.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Food and Chemical Toxicology - Volume 92, June 2016, Pages 165-176
Journal: Food and Chemical Toxicology - Volume 92, June 2016, Pages 165-176
نویسندگان
Daniel R. Doerge, Kellie A. Woodling, Mona I. Churchwell, Stefanie C. Fleck, William G. Helferich,