کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5849581 | 1561758 | 2015 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Carcinogenicity of glycidamide in B6C3F1 mice and F344/N rats from a two-year drinking water exposure
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کلمات کلیدی
BMDTumorigenicityBMDLNCTRPWGpathology working groupBioassay - آزمایش زیستیAcrylamide - آکریل آمیدanalysis of variance - تحلیل واریانسANOVA - تحلیل واریانس Analysis of variancebenchmark dose - دوز معادلNational Center for Toxicological Research - مرکز ملی تحقیقات سم شناسیMice - موشRats - موش صحراییGlycidamide - گلیسیدامید
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش تغذیه
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Carcinogenicity of glycidamide in B6C3F1 mice and F344/N rats from a two-year drinking water exposure Carcinogenicity of glycidamide in B6C3F1 mice and F344/N rats from a two-year drinking water exposure](/preview/png/5849581.png)
چکیده انگلیسی
Acrylamide is a contaminant in baked and fried starchy foods, roasted coffee, and cigarette smoke. Previously we reported that acrylamide is a multi-organ carcinogen in B6C3F1 mice and F344/N rats, and hypothesized that acrylamide is activated to an ultimate carcinogen through metabolism to the epoxide glycidamide. We have now examined the carcinogenic effects of glycidamide administered at 0, 0.0875, 0.175, 0.35 and 0.70Â mM in drinking water to the same strains of rodents for two years. In male and female mice, there were significant increases in tumors of the Harderian gland, lung, forestomach, and skin. Female mice also had an increased incidence of tumors of the mammary gland and ovary. In male and female rats, there were significant increases in thyroid gland and oral cavity neoplasms and mononuclear cell leukemia. Male rats also had increases in tumors of the epididymis/testes and heart, while female rats demonstrated increases in tumors of the mammary gland, clitoral gland, and forestomach. A similar spectrum of tumors was obtained in mice and rats administered acrylamide. These data indicate that, under the conditions of these bioassays, acrylamide is efficiently metabolized to glycidamide and that the carcinogenic activity of acrylamide is due to its conversion into glycidamide.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Food and Chemical Toxicology - Volume 86, December 2015, Pages 104-115
Journal: Food and Chemical Toxicology - Volume 86, December 2015, Pages 104-115
نویسندگان
Frederick A. Beland, Greg R. Olson, Maria C.B. Mendoza, M. Matilde Marques, Daniel R. Doerge,